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Table of Contents Contributing Authors David Wilson 5. Dean, Robert D.

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Monsen, and Jonathan B. Chaires 6. Parkinson and Gavin W. Shankar Balasubramanian: ku. This article has been cited by other articles in PMC. Abstract Graphical abstract. Open in a separate window. Abstract Guanine-rich nucleic acids can fold into non-canonical DNA secondary structures called G-quadruplexes.

Introduction Guanine-rich nucleic acids are well known for their ability to adopt non Watson—Crick hydrogen-bonded structures [1,2]. Structure-based methods 2. Theoretical mapping based on computational analysis Biophysical studies on G-quadruplexes have provided the knowledge to enable the computational prediction of where putative G-quadruplex forming sequences PQS occur in genomes [40]. Experimental mapping based on protein immunoprecipitation The identification of selective G-quadruplex binding proteins provides an opportunity to locate these structures in cellular DNA [52].

Experimental mapping of DNA sites by small molecule-affinity isolation Natural products and synthetic small molecules are powerful tools to enable the investigation of biology.

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Biased approach to identify G-quadruplex structures in human genomic DNA. Cellular imaging In cellulo sensing of G-quadruplex structure can be achieved by either using modified antibodies [68] , G-quadruplex based aptamers [92] or by using small molecules that selectively light up as response to the binding [93—95].

Correlation of G-quadruplex structure with function The existence and function of each individual G-quadruplex structure mapped in the human genome is still questionable. Discussions and Conclusion The invention and development of general methods for mapping G-quadruplex forming sequences in the genome and the transcriptome of cells remains a major challenge in biology. References 1. Gellert M.

Sen D. Davis J. Burge S. Nucleic Acids Res. Bugaut A. Zhang A. Hazel P. Rachwal P. Balasubramanian S. Drug Disc. Folini M.

G-Quadruplex Nucleic Acids

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G-Quadruplex DNA - Methods and Protocols | Peter Baumann | Springer

Balasubramanian, Nucleic Acids Res. Sarkies, P. Murat, L. Phillips, K. Patel, S. Balasubramanian, J. Sale, Nucleic Acids Res. Cell Cycle. London T. Sanders C. Huber M. Johnson J. Kamath-Loeb A. PloS one. Todd A. Huppert J. Kikin O. QGRS mapper: A web-based server for predicting g-quadruplexes in nucleotide sequences. Kostadinov R. Eddy J. Rawal P. Genome Res. Stegle O. Sissi C.